About Us
Learn More About AEYECARE Through Our Works
Our Studies and Reach in Africa
ASPIRE which stands for Automated Screening of Plasmodium Infection in Retinal Exams was validated across 26 clinics in 4 countries on >2500 patients
Aspire
The eyes as windows into the body Did you know that the eye is the only place in the body where both neurons and blood vessels can be seen without surgery? This makes the eyes invaluable as a way to gather information about what is happening inside us – both with the brain and our blood. With the right expertise and equipment, someone looking at the blood vessels in our eye can tell if we have high blood pressure, diabetes or heart disease.
Challenge with Diagnosis
Cerebral Malaria is highly misdiagnosed. It appears it gives Physicians tunnel vision. Finding malaria parasites in a blood smear or a positive rapid diagnostic test (RDT) in a sick child does not necessarily mean that malaria is the cause of the illness. Yet severe malaria is the usual diagnosis in a hospitalised febrile African child with a positive blood smear or RDT. Differentiating severe bacterial infections from severe malaria is difficult, and the two commonly coexist. This is where ASPIRE comes in to help differentiate this.
We are enhancing the diagnosis of Cerebral Malaria in under-5.
The pathogenesis of malarial retinopathy is associated with that of cerebral malaria, i.e. sequestration of infected red blood cells in retinal and cerebral microvasculature, causing vessel obstruction and reduced blood flow resulting in downstream ischemia and hypoxia.
We are enhancing the diagnosis of Cerebral Malaria in under-5.
By combining AI and advancements in retina imaging technology, we have brought a much-needed screening tool in managing Cerebral malaria in unconscious children.
The Cerebral Malaria Mortality
Without treatment, Cerebral Malaria (CM) is nearly 100% fatal. Mortality is decreased by effective antimalarials but remains unacceptably high, at 15%–20%. The WHO defines CM as an unarousable state (Glasgow coma score <11 in adults or a Blantyre coma score <3). CM is responsible for almost half of the mortalities from Severe Malaria.
The Malaria Burden
The Sub-Saharan African Region carries a disproportionately high share of the global malaria burden. In 2022, the Region was home to 94% of malaria cases (233 million) and 95% (580 000) of malaria deaths. Children under 5 accounted for about 80% of all malaria deaths in the Region.
What is ASPIRE
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A Visual Journey With AEYECARE
Our Projects
ENHANCING ASPIRE WITH LARGE LANGUAGE MODELS
- This project aims to enhance ASPIRE’s capabilities by integrating a large language model. This update will allow health workers to input clinical history, physical examination findings, investigation results, and relevant information, generating treatment guidelines even in facilities lacking pediatric specialists.
- “CM real-time incidence App”.
- “CM incidence prediction based on weather”
MALARIA RETINOPATHY DETECTION BY ASPIRE
- Almost half of the mortality from Malaria is from Cerebral Malaria. Why? Because with Cerebral Malaria and all other forms of severe malaria being able to identify the complication and treat it on time is a vital part of saving lives from Cerebral Malaria.
- With ASPIRE Cerebral Malaria can be diagnosed in the first hour of arrival at the children emergency. The key benefits here include:
- Accurate Detection : Malarial retinopathy detection helps to eliminates confusion on ongoing infections, ensuring a accurate detection to guide diagnosis and treatment.
- Triage Support: During peak rainy seasons or overcrowded emergency rooms, Malarial retinopathy detection aids in triaging sick children by identifying those with a poor prognosis, enabling prioritized care.
- Treatment Monitoring: The blood supply to the eyes eyes is an extension of the brain’s blood supply. Malarial retinopathy detection allows health workers to monitor treatment effectiveness by tracking changes in malaria retinopathy lesions through daily retinal examinations.
- Error Reduction: Malarial retinopathy detection minimizes misdiagnoses, providing accurate data on cerebral malaria incidence.
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